J. Kutzsche: search on Z-Library

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1

Safety and pharmacokinetics of the orally available antiprionic compound PRIâ002: A single and multiple ascending dose phase I study

Kutzsche, Janine, JÃ¼rgens, Dagmar, Willuweit, Antje, Adermann, Knut, Fuchs, Carola, Simons, Stefanie, Windisch, Manfred, HÃ¼mpel, Michael, Rossberg, Wolfgang, Wolzt, Michael, Willbold, Dieter

Journal:

Alzheimer s & Dementia Translational Research & Clinical Interventions

Year:

2020

Language:

english

File:

PDF, 848 KB

english, 2020

2

In Vitro Potency and Preclinical Pharmacokinetic Comparison of All-D-Enantiomeric Peptides Developed for the Treatment of Alzheimer’s Disease

Schartmann, Elena, Schemmert, Sarah, Niemietz, Nicole, Honold, Dominik, Ziehm, Tamar, Tusche, Markus, Elfgen, Anne, Gering, Ian, Brener, Oleksandr, Shah, Nadim Joni, Langen, Karl-Josef, Kutzsche, Jani

Journal:

Journal of Alzheimer's Disease

Year:

2018

Language:

english

File:

PDF, 599 KB

english, 2018

3

Gesteigerte Wirksamkeit durch Synergismus: Verknüpfung unabhängiger Wirkstoffklassen zu Hybridsubstanzen

Dr. Andreas Müller-Schiffmann, Dr. Julia März-Berberich, Dr. Aksana Andreyeva, Dr. Raik Rönicke, Dr. Dirk Bartnik, Dr. Oleksandr Brener, Dr. Janine Kutzsche, Dr. Anselm H. C. Horn, Dipl.-Chem. Marco H

Journal:

Angewandte Chemie

Year:

2010

Language:

german

File:

PDF, 606 KB

german, 2010

4

Combining Independent Drug Classes into Superior, Synergistically Acting Hybrid Molecules

Dr. Andreas Müller-Schiffmann, Dr. Julia März-Berberich, Dr. Aksana Andreyeva, Dr. Raik Rönicke, Dr. Dirk Bartnik, Dr. Oleksandr Brener, Dr. Janine Kutzsche, Dr. Anselm H. C. Horn, Dipl.-Chem. Marco H

Journal:

Angewandte Chemie International Edition

Year:

2010

Language:

english

File:

PDF, 620 KB

english, 2010

5

Severe complications during the management of a child with late presentation of a diaphragmatic hernia

S. Kutzsche, G. K. Sangolt, O. Schistad, S. Sunde

Journal:

Acta Anaesthesiologica Scandinavica

Year:

2003

Language:

english

File:

PDF, 616 KB

english, 2003

6

Beeinflussung von Transplantattumoren durch Tumorlipoide

Journal:

Medical Microbiology and Immunology

Year:

1949

Language:

german

File:

PDF, 602 KB

german, 1949

7

Elektronenmikroskopische Untersuchungen an verfetteten Fibroblastenkulturen nach verzögerter Umsetzung

W. Schwarz, H. -J. Merker, A. Kutzsche

Journal:

Cell and Tissue Research

Year:

1964

Language:

german

File:

PDF, 3.32 MB

german, 1964

8

Elektronenmikroskopische Untersuchungen über die Fibrillogenese in Fibroblastenkulturen

W. Schwarz, H. -J. Merker, A. Kutzsche

Journal:

Cell and Tissue Research

Year:

1962

Language:

german

File:

PDF, 5.50 MB

german, 1962

9

Zeitschriften

H. J. Endres, Friedrich Dosch, F. Dietel, Kutzsche, Röper-Böttger, Schwiegk, Oberdisse

Journal:

Journal of Molecular Medicine

Year:

1953

Language:

german

File:

PDF, 1.13 MB

german, 1953

10

Elektronenmikroskopische Untersuchungen über die anabole und katabole Wirkung von Dexamethason und Methenolonester auf Fibroblasten in vitro

W. Schwarz, A. Kutzsche

Journal:

Journal of Molecular Medicine

Year:

1966

File:

PDF, 856 KB

1966

11

Hemodynamic Changes and Systemic Activation of Coagulation and Fibrinolysis During Controlled Endotoxemia in Pigs

Stefan Kutzsche, Ellen Schlichting, Trude Aspelin, Torstein Lyberg

Journal:

Thrombosis Research

Year:

2000

Language:

english

File:

PDF, 163 KB

english, 2000

12

Cerebral nitric oxide concentration and microcirculation during hypercapnia, hypoxia, and high intracranial pressure in pigs

Ole J. Kirkeby, Stefan Kutzsche, Cecilie Risöe, Ingunn R. Rise

Journal:

Journal of Clinical Neuroscience

Year:

2000

Language:

english

File:

PDF, 164 KB

english, 2000

13

Neonatal seizures with reversible EEG changes after antenatal venlafaxine exposure

Haukland, Lars Utne, Kutzsche, Stefan, Hovden, Inger Anette Hynås, Stiris, Tom

Journal:

Acta Paediatrica

Year:

2013

Language:

english

File:

PDF, 123 KB

english, 2013

14

Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and webs

Rouvinski, A., Karniely, S., Kounin, M., Moussa, S., Goldberg, M. D., Warburg, G., Lyakhovetsky, R., Papy-Garcia, D., Kutzsche, J., Korth, C., Carlson, G. A., Godsave, S. F., Peters, P. J., Luhr, K.,

Journal:

The Journal of Cell Biology

Year:

2014

Language:

english

File:

PDF, 3.61 MB

english, 2014

15

What do paediatric trainees require from their clinical supervisors?

Kutzsche, Stefan, Kutzsche, Hildegunn, Dornan, Tim

Journal:

Acta Paediatrica

Year:

2014

Language:

english

File:

PDF, 90 KB

english, 2014

16

A Novel Canning Technology for Forging of Gamma-TiAl Alloys

Zhang, J., Kutzsche, Anja, Rosenberg, K., Leyens, Christoph, Viehweger, B.

Journal:

Materials Science Forum

Year:

2007

Language:

english

File:

PDF, 4.03 MB

english, 2007

17

Influence of Mechanical Surface Treatments on the Fatigue Performance of the Gamma TiAl Alloy Ti-45Al-9Nb-0.2C

Lindemann, J., Kutzsche, Anja, Oehring, Michael, Appel, Fritz

Journal:

Materials Science Forum

Year:

2007

Language:

english

File:

PDF, 606 KB

english, 2007

18

When Life-Sustaining Treatment Is Withdrawn and the Patient Doesn't Die

Kutzsche, S., Partridge, J. C., Leuthner, S. R., Lantos, J. D.

Journal:

Year:

2013

Language:

english

File:

PDF, 623 KB

english, 2013

19

Hydrogen Peroxide Production in Leukocytes during Cerebral Hypoxia and Reoxygenation with 100% or 21% Oxygen in Newborn Piglets

Kutzsche, Stefan, Ilves, Pilvi, Kirkeby, Ole Jorgen, Saugstad, Ola Didrik

Journal:

Pediatric Research

Year:

2001

Language:

english

File:

PDF, 104 KB

english, 2001

20

Pharmacokinetic Properties of a Noveld-Peptide Developed to be Therapeutically Active Against Toxic β-Amyloid Oligomers

L. H. E. Leithold, N. Jiang, J. Post, T. Ziehm, E. Schartmann, J. Kutzsche, N. J. Shah, J. Breitkreutz, K. Langen, A. Willuweit, D. Willbold

Journal:

Pharmaceutical Research

Year:

2016

Language:

english

File:

PDF, 849 KB

english, 2016

21

Structure characterization of unexpected covalent O-sulfonation and ion-pairing on an extremely hydrophilic peptide with CE-MS and FT-ICR-MS

Pattky, Martin, Nicolardi, Simone, Santiago-Schübel, Beatrix, Sydes, Daniel, van der Burgt, Yuri E. M., Klein, Antonia N., Jiang, Nan, Mohrlüder, Jeannine, Hänel, Karen, Kutzsche, Janine, Funke, S. A.

Journal:

Analytical and Bioanalytical Chemistry

Year:

2015

Language:

english

File:

PDF, 2.28 MB

english, 2015

22

Pharmacokinetic properties of tandem d-peptides designed for treatment of Alzheimer's disease

Leithold, Leonie H.E., Jiang, Nan, Post, Julia, Niemietz, Nicole, Schartmann, Elena, Ziehm, Tamar, Kutzsche, Janine, Shah, N. Jon, Breitkreutz, Jörg, Langen, Karl-Josef, Willuweit, Antje, Willbold, Di

Journal:

European Journal of Pharmaceutical Sciences

Year:

2016

Language:

english

File:

PDF, 1.31 MB

english, 2016

23

CHARACTERIZATION OF D-ENANTIOMERIC PEPTIDES BINDING TO MONOMERIC AMYLOID BETA (1-42) IDENTIFIED BY A COMPETITIVE MIRROR IMAGE PHAGE DISPLAY

Rudolph, Stephan, Kutzsche, Janine, Klein, Antonia Nicole, Frenzel, Daniel, Willbold, Dieter

Journal:

Alzheimer's & Dementia

Year:

2014

Language:

english

File:

PDF, 155 KB

english, 2014

24

Effects of adenosine on extravascular lung water content in endotoxemic pigs

Kutzsche, Stefan, Lyberg, Torstein, Bjertnaes, Lars J.

Journal:

Critical Care Medicine

Year:

2001

Language:

english

File:

PDF, 116 KB

english, 2001

25

CHARACTERIZATION OF D-ENANTIOMERIC PEPTIDES DERIVED FROM D3 FOR TREATMENT OF ALZHEIMER'S DISEASE

Klein, Antonia Nicole, Tusche, Markus, Schlosser, Christine, Bartnik, Dirk, Kutzsche, Janine, Willbold, Dieter

Journal:

Alzheimer's & Dementia

Year:

2014

Language:

english

File:

PDF, 155 KB

english, 2014

26

Cerebral hypoxemia-ischemia and reoxygenation with 21% or 100% oxygen in newborn piglets: Effects on extracellular levels of excitatory amino acids and microcirculation

Sol??s, Anne-Beate, Kutzsche, Stefan, Vinje, Morten, Saugstad, Ola D.

Journal:

Pediatric Critical Care Medicine

Year:

2001

Language:

english

File:

PDF, 116 KB

english, 2001

27

Increase of Positive Net Charge and Conformational Rigidity Enhances the Efficacy of d -Enantiomeric Peptides Designed to Eliminate Cytotoxic Aβ Species

Ziehm, Tamar, Brener, Oleksandr, van Groen, Thomas, Kadish, Inga, Frenzel, Daniel, Tusche, Markus, Kutzsche, Janine, Reiß, Kerstin, Gremer, Lothar, Nagel-Steger, Luitgard, Willbold, Dieter

Journal:

ACS Chemical Neuroscience

Year:

2016

Language:

english

File:

PDF, 3.31 MB

english, 2016

28

SURPRISINGLY HIGH RESISTANCE OF SMALL ALL-D-ENANTIOMERIC PEPTIDES AGAINST METABOLIC DEGRADATION AND MODIFICATIONS

Elfgen, Anne, Kutzsche, Janine, Willbold, Dieter

Journal:

Alzheimer's & Dementia

Year:

2016

Language:

english

File:

PDF, 50 KB

english, 2016

29

RAISING AVAILABLE BRAIN CONCENTRATIONS OF A POTENTIAL ALZHEIMER’S DISEASE DRUG CANDIDATE BY PEPTIDE CYCLIZATION

Schartmann, Anna Elena, Schemmert, Sarah, Ziehm, Tamar, Leithold, Leonie H.E., Jiang, Nan, Kutzsche, Janine, Willuweit, Antje, Willbold, Dieter

Journal:

Alzheimer's & Dementia

Year:

2016

Language:

english

File:

PDF, 50 KB

english, 2016

30

THERAPEUTIC TREATMENT WITH AN ALL-D-ENANTIOMERIC PEPTIDE IMPROVES COGNITIVE IMPAIRMENT IN OLD APPSWE/PS1 TRANSGENIC MICE

Schemmert, Sarah, Schartmann, Anna Elena, Kutzsche, Janine, Willuweit, Antje, Willbold, Dieter

Journal:

Alzheimer's & Dementia

Year:

2016

Language:

english

File:

PDF, 47 KB

english, 2016

31

Biophysical Studies of the Interaction between Optimized Peptides and Amyloid-Beta Elucidate a Completely Novel Binding Mode

Ziehm, Tamar, Klein, Antonia, Kutzsche, Janine, Willbold, Dieter

Journal:

Biophysical Journal

Year:

2017

Language:

english

File:

PDF, 43 KB

english, 2017

32

QIAD assay for quantitating a compound’s efficacy in elimination of toxic Aβ oligomers

Brener, Oleksandr, Dunkelmann, Tina, Gremer, Lothar, van Groen, Thomas, Mirecka, Ewa A., Kadish, Inga, Willuweit, Antje, Kutzsche, Janine, Jürgens, Dagmar, Rudolph, Stephan, Tusche, Markus, Bongen, Pa

Journal:

Scientific Reports

Year:

2015

Language:

english

File:

PDF, 1.31 MB

english, 2015

33

Optimization of D-peptides for Aβ monomer binding specificity enhances their potential to eliminate toxic Aβ oligomers

Klein, Antonia Nicole, Ziehm, Tamar, van Groen, Thomas, Kadish, Inga, Elfgen, Anne, Tusche, Markus, Thomaier, Maren, Reiss, Kerstin, Brener, Oleksandr, Gremer, Lothar, Kutzsche, Janine, Willbold, Diet

Journal:

ACS Chemical Neuroscience

Year:

2017

Language:

english

File:

PDF, 1.80 MB

english, 2017

34

Surprisingly high stability of the Aβ oligomer eliminating all- d -enantiomeric peptide D3 in media simulating the route of orally administered drugs

Elfgen, Anne, Santiago-Schübel, Beatrix, Gremer, Lothar, Kutzsche, Janine, Willbold, Dieter

Journal:

European Journal of Pharmaceutical Sciences

Year:

2017

Language:

english

File:

PDF, 774 KB

english, 2017

35

Comparison of blood-brain barrier penetration efficiencies between linear and cyclic all- d -enantiomeric peptides developed for the treatment of Alzheimer's disease

Schartmann, Elena, Schemmert, Sarah, Ziehm, Tamar, Leithold, Leonie H.E., Jiang, Nan, Tusche, Markus, Jon Shah, N., Langen, Karl-Josef, Kutzsche, Janine, Willbold, Dieter, Willuweit, Antje

Journal:

European Journal of Pharmaceutical Sciences

Year:

2017

Language:

english

File:

PDF, 1.04 MB

english, 2017

36

Development and validation of an UHPLC-ESI-QTOF-MS method for quantification of the highly hydrophilic amyloid-β oligomer eliminating all- D -enantiomeric peptide RD2 in mouse plasma

Hupert, Michelle, Elfgen, Anne, Schartmann, Elena, Schemmert, Sarah, Buscher, Brigitte, Kutzsche, Janine, Willbold, Dieter, Santiago-Schübel, Beatrix

Journal:

Journal of Chromatography B

Year:

2018

Language:

english

File:

PDF, 489 KB

english, 2018

37

TREATMENT WITH AN ALL D-ENANTIOMERIC PEPTIDE IMPROVES COGNITIVE AND MOTORIC IMPAIRMENT IN TWO DIFFERENT ALZHEIMER MOUSE MODELS

Schemmert, Sarah, Schartmann, Anna Elena, Kutzsche, Janine, Willuweit, Antje, Willbold, Dieter

Journal:

Alzheimer's & Dementia

Year:

2017

Language:

english

File:

PDF, 347 KB

english, 2017

38

CYCLIC D-ENANTIOMERIC PEPTIDE TARGETING AMYLOID-BETA IN ALZHEIMER’S DISEASE

Schartmann, Anna Elena, Schemmert, Sarah, Leithold, Leonie H.E., Jiang, Nan, Ziehm, Tamar, Willuweit, Antje, Kutzsche, Janine, Willbold, Dieter

Journal:

Alzheimer's & Dementia

Year:

2017

Language:

english

File:

PDF, 350 KB

english, 2017

39

SURPRISINGLY HIGH RESISTANCE OF Aβ OLIGOMER ELIMINATING ALL-D-ENANTIOMERIC PEPTIDES AGAINST METABOLIZATION BY ENZYMES CONTAINED IN THE GASTROINTESTINAL TRACT, BLOOD, LIVER AND BRAIN

Elfgen, Anne, Santiago-Schübel, Beatrix, Sacchi, Silvia, Pollegioni, Loredano, Kutzsche, Janine, Willbold, Dieter

Journal:

Alzheimer's & Dementia

Year:

2017

Language:

english

File:

PDF, 218 KB

english, 2017

40

Inhibition of Amyloid Aβ Aggregation by High Pressures or Specific D-Enantiomeric Peptides

Cavini, Italo A., Munte, Claudia E., Beck Erlach, Markus, van Groen, Thomas, Kadish, Inga, Zhang, Tao, Ziehm, Tamar, Nagel-Steger, Luitgard, Kutzsche, Janine, Kremer, Werner, Willbold, Dieter, Kalbitz

Journal:

Chemical Communications

Year:

2018

Language:

english

File:

PDF, 734 KB

english, 2018

41

Effects of Hypoxia and Reoxygenation with 21% and 100%-Oxygen on Cerebral Nitric Oxide Concentration and Microcirculation in Newborn Piglets

Kutzsche, Stefan, Kirkeby, Ole J., Rise, Ingunn R., Saugstad, Ola D.

Journal:

Biology of the Neonate

Year:

1999

Language:

english

File:

PDF, 420 KB

english, 1999

42

Einige mikrobiologische Besonderheiten neuerer Sulfanilamide

Journal:

Year:

1964

Language:

german

File:

PDF, 1.00 MB

german, 1964

43

Cerebral Neutrophil Respiratory Burst in Newborn Piglets during Asphyxia and Resuscitation with 100% or 21% Oxygen

Kutzsche, S, Ilves, P, Kirkeby, O J, Saugstad, O D

Journal:

Pediatric Research

Year:

1999

File:

PDF, 70 KB

1999

44

Preclinical Pharmacokinetic Studies of the Tritium Labelled D-Enantiomeric Peptide D3 Developed for the Treatment of Alzheimer´s Disease

Jiang, Nan, Leithold, Leonie H. E., Post, Julia, Ziehm, Tamar, Mauler, Jörg, Gremer, Lothar, Cremer, Markus, Schartmann, Elena, Shah, N. Jon, Kutzsche, Janine, Langen, Karl-Josef, Breitkreutz, Jörg, W

Journal:

Year:

2015

Language:

english

File:

PDF, 2.91 MB

english, 2015

45

Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity

Rudolph, Stephan, Klein, Antonia Nicole, Tusche, Markus, Schlosser, Christine, Elfgen, Anne, Brener, Oleksandr, Teunissen, Charlotte, Gremer, Lothar, Funke, Susanne Aileen, Kutzsche, Janine, Willbold,

Journal:

Year:

2016

Language:

english

File:

PDF, 5.54 MB

english, 2016

46

Aβ Oligomer Elimination Restores Cognition in Transgenic Alzheimer’s Mice with Full-blown Pathology

Schemmert, Sarah, Schartmann, Elena, Zafiu, Christian, Kass, Bettina, Hartwig, Sonja, Lehr, Stefan, Bannach, Oliver, Langen, Karl-Josef, Shah, Nadim Joni, Kutzsche, Janine, Willuweit, Antje, Willbold,

Journal:

Molecular Neurobiology

Year:

2018

Language:

english

File:

PDF, 1.23 MB

english, 2018

47

Comprehensive Characterization of the Pyroglutamate Amyloid-β Induced Motor Neurodegenerative Phenotype of TBA2.1 Mice

Dunkelmann, Tina, Schemmert, Sarah, Honold, Dominik, Teichmann, Kerstin, Butzküven, Elke, Demuth, Hans-Ulrich, Shah, Nadim Joni, Langen, Karl-Josef, Kutzsche, Janine, Willbold, Dieter, Willuweit, Antj

Journal:

Journal of Alzheimer's Disease

Year:

2018

Language:

english

File:

PDF, 2.00 MB

english, 2018

48

Large-Scale Oral Treatment Study with the Four Most Promising D3-Derivatives for the Treatment of Alzheimer’s Disease

Kutzsche, Janine, Schemmert, Sarah, Tusche, Markus, Neddens, Jörg, Rabl, Roland, Jürgens, Dagmar, Brener, Oleksandr, Willuweit, Antje, Hutter-Paier, Birgit, Willbold, Dieter

Journal:

Year:

2017

Language:

english

File:

PDF, 1014 KB

english, 2017

49

John Langdon Down (1828-1896) - a pioneer in caring for mentally disabled patients

Kutzsche, Stefan

Journal:

Acta Paediatrica

Year:

2018

Language:

english

File:

PDF, 483 KB

english, 2018

50

Deceleration of the neurodegenerative phenotype in pyroglutamate-Aβ accumulating transgenic mice by oral treatment with the Aβ oligomer eliminating compound RD2

Schemmert, Sarah, Schartmann, Elena, Honold, Dominik, Zafiu, Christian, Ziehm, Tamar, Langen, Karl-Josef, Shah, Nadim Joni, Kutzsche, Janine, Willuweit, Antje, Willbold, Dieter

Journal:

Neurobiology of Disease

Year:

2018

Language:

english

File:

PDF, 7.21 MB

english, 2018